page3
3
(2)
心血管系統：大失血、已給予一次輸液治療後仍貧血（低於
20
％）
Cardiovascular system: blood loss or anemia.
(3)
消化系統：嚴重嘔吐或下痢，消化道阻塞，套疊，腹膜炎，內臟摘除手
術
Gastrointestinal
system:
severe
vomiting
or
diarrhea,
obstruction,
intussuception; peritonitis, evisceration(immediate euthanasia required).
(4)
泌尿道系統：腎衰竭（
BUN, creatinine, uroperitoneum
的提升）
Urogenital system: renal failure characterized by elevated BUN, creatinine or
uroperitoneum.
(5)
神經系統：中樞神經抑制、震顫、癱瘓（其中任一肢或以上）、對止痛
劑治療無效之疼痛
Nervous
system:
CNS
depression,
seizures,
paralysis
of
one
or
more
extremities; pain unresponsive to analgesic therapy.
(6)
肌肉骨骼系統：肌肉受損或骨折使肢體喪失功能（實驗預期發生並通過
IACUC
審核除外）
Musculoskeletal system: muscle damage or fracture resulting in inability to
use the limb, unless anticipated as part of the study.
(7)
皮膚：無法治癒之傷口、重複性自殘或二級以上之保溫墊燙傷
Integumentary system: Non-healing wounds, repeated self-trauma, second or
third degree heating pad burns.
7.
腫瘤生成終點評估
Tumorigenesis Endpoints Assessment
無論自發性或是實驗接種的腫瘤，均應進行實驗終點評估。當動物身上發現
腫瘤，每週應至少檢查兩次腫瘤生長情形，兩次檢查的間隔不可超過四天。
只要符合下列任一項情況即需將動物安樂死。
Tumors may occur spontaneously, or be experimentally induced through
transplantation or administration of carcinogens. Animals in which tumors are
growing should be checked at least two times weekly, at intervals no greater than
four days apart. The clinical signs listed below are expected as part of the
experiment and appropriate measures are taken to minimize pain or discomfort in
the animals.
1)
單一腫瘤的重量超過動物體重的
10
％，或是成年小鼠腫瘤平均直徑超過
20mm
，或是成年大鼠腫瘤平均直徑超過
40mm
。
A tumor burden greater than 10% body weight, and in an adult mouse, a mean
tumor diameter exceeding 20 mm or in an adult rat, a mean tumor diameter
exceeding 40 mm.
PDF
檔案使用
"pdfFactory Pro"
試用版本建立
www.pdffactory.com